The average success rate of IVF treatment is around 60%. There are many factors that affect the success rate. Therefore, it cannot be expected to be the same in every couple. In spite of progressive developments and new technologies in IVF, in some cases, the desired success rates may not be achieved. One of the most important factors that determines success rate is the age. As the age progresses, both the egg number and egg quality is reduced. For women under the age of 35, the success rate is around 60%, while towards the age of 40, this rate will be reduced by half and drop to 20%. Other factors that will affect the success rate of IVF treatment are:
- The woman’s age and ovarian capacity
- The number and quality of eggs obtained during the IVF treatment
- The causes of infertility and duration
- Whether the female has conceived before or not
- Sperm count and quality
- Previous diseases
- Treatments, and the patient alignment.
- The transfer technique and the quality of embryos transferred
- The presence of polyps or fibroids, which can prevent the adhesion of the embryo in the uterus
- The IVF Centre’s quality, the training and experience of personnel
Before starting a new IVF treatment to patients who have had the treatment and failed before, a detailed examination will be needed in order to determine the cause of failure. The presence of polyps or fibroids which can prevent the adhesion should be determined and if there is any, these should be treated. before starting the IVF treatment. For this purpose, the female can have a hysterosalpingography, or hysteroscopy done. Endometriosis will also affect the success rate. If detected, removing or tying the tubes will increase the success rate. Immune and clotting disorders should be examined. If a clotting disorder is detected, the appropriate treatment should be applied to the patient. In clotting disorders, blood thinners are used.
In immune system disorders, paternal lymphocyte vaccine can be used. In this method, the blood sample taken from the male will be differentiated to lymphocyte cells and will be injected to the female’s arm in 4 different places. This procedure is applied 3 times before IVF treatment, and 2 times after the treatment. The aim of this treatment is to prevent harm to the developing baby from the immune cells which can form in the mother’s womb. In order to obtain good quality embryos, and to increase the adhesion assisted hatching, application of artificial intrauterine (endometrial co-culture) and blastocyst transfer (5th day embryo transfer) can be done as well.
As with every treatment, factors such as avoiding stress and a healthy lifestyle will have a positive impact on the IVF treatment. The patient should have a healthy diet before and after the treatment and avoid smoking and alcohol.